Low-Dose Tadalafil (Off-Label Longevity Use)
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Daily low-dose PDE5-inhibitor use (commonly 2.5–5 mg) for vascular health, exercise tolerance, and the Alzheimer’s-incidence signal in the prescription-database literature. The mechanism (NO-cGMP signaling) is well-established for vascular function; the longevity claims rest on observational prescription-cohort signals, not RCTs.